Aqua-mediated one-pot synthesis and aromatization of pyrimido-fused 1,4-dihydropyridine derivatives using ammonium salts

Dipyrimidine-fused pyridine derivatives were synthesized using 1,3-diketone, aldehyde, different ammonium salts, and water, as the solvent. Aromatization was observed when ammonium nitrate was used as the source of nitrogen, and thus, dipyrimidine-fused pyridine derivatives were synthesized in one-pot synthetic procedure. This environmentally benign procedure leads to high yield of products (80%-90%) in a single step, with greater purity using water as the solvent.