Generalized macro level models of amino acid sequences using passive electrical circuits

被引:0
|
作者
Marshall, R. [1 ]
机构
[1] Plymouth State Univ, Comp Sci & Technol Dept, Plymouth, NH 03264 USA
关键词
Modeling and simulation; bioinformatics; passive electrical circuits; HUMAN GENOME; MATRICES;
D O I
暂无
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this paper, we discuss four types of electrical network circuits have been used for modeling amino acid sequences at the gross molecular level. The standard 20 amino acids have been partitioned into mutually exclusive partitions based on their chemical and structural properties and each partition is assigned a distinct electrical circuit. This enables the construction of electrical networks for representing any amino acid sequence. These networks have been analyzed to establish putative relationships between a network's electrical response and known behavior of protein sequences. To aid in the analysis of circuit response, we have also developed a unique visualization technique. Similar circuits have been used to model DNA/RNA sequences as well as non-biological strings which have applications in message encryption and computer security.
引用
收藏
页码:608 / 622
页数:15
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