Inducible gene expression in mammalian cells and transgenic mice

被引：91
|
作者：
Saez, E
No, D
West, A
Evans, RM
机构：
[1] Howard Hughes Medical Institute, Gene Expression Lab., Salk Institute, 10010 North Torrey Pines Road, San Diego
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0958-1669(97)80037-7
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Advances in biomedicine have accentuated the need to develop methods to deliberately modulate gene activity. In addition to improved versions of the system based on components of the tetracycline resistance operon, several strategies have recently emerged to control gene function at the transcriptional level. Particularly promising are approaches based on non-mammalian steroid hormones, and on small molecules that bind immunophilins.
引用
收藏
页码：608 / 616
页数：9
相关论文
共 50 条
  • [1] Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    No, D
    Yao, TP
    Evans, RM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) : 3346 - 3351
  • [2] Inducible gene expression and gene modification in transgenic mice
    Jaisser, F
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2000, 11 (11): : S95 - S100
  • [3] Inducible gene expression in the nervous system of transgenic mice
    Gingrich, JR
    Roder, J
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 : 377 - 405
  • [4] Inducible podocyte-specific gene expression in transgenic mice
    Shigehara, T
    Zaragoza, C
    Kitiyakara, C
    Takahashi, H
    Lu, HY
    Moeller, M
    Holzman, LB
    Kopp, JB
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (08): : 1998 - 2003
  • [5] Bacterial xylanase expression in mammalian cells and transgenic mice
    Fontes, CMGA
    Ali, S
    Gilbert, HJ
    Hazlewood, GP
    Hirst, BH
    Hall, J
    [J]. JOURNAL OF BIOTECHNOLOGY, 1999, 72 (1-2) : 95 - 101
  • [6] Gas-inducible transgene expression in mammalian cells and mice
    Wilfried Weber
    Markus Rimann
    Manuela Spielmann
    Bettina Keller
    Marie Daoud-El Baba
    Dominique Aubel
    Cornelia C Weber
    Martin Fussenegger
    [J]. Nature Biotechnology, 2004, 22 : 1440 - 1444
  • [7] Gas-inducible transgene expression in mammalian cells and mice
    Weber, W
    Rimann, M
    Spielmann, M
    Keller, B
    Daoud-El Baba, M
    Aubel, D
    Weber, CC
    Fussenegger, M
    [J]. NATURE BIOTECHNOLOGY, 2004, 22 (11) : 1440 - 1444
  • [8] Phospholamban gene expression in cells and transgenic mice
    Haghighi, K
    Kadambi, VJ
    Koss, KL
    Kranias, EG
    [J]. BIOPHYSICAL JOURNAL, 1997, 72 (02) : TU193 - TU193
  • [9] INDUCIBLE EXPRESSION OF AN HSP68-LACZ HYBRID GENE IN TRANSGENIC MICE
    KOTHARY, R
    CLAPOFF, S
    DARLING, S
    PERRY, MD
    MORAN, LA
    ROSSANT, J
    [J]. DEVELOPMENT, 1989, 105 (04): : 707 - &
  • [10] Inducible gene expression in the proximal or cortical collecting tubules of transgenic mice.
    Jaillard, C
    Freundlieb, S
    Bujard, H
    Jaisser, F
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1997, 8 : A0169 - A0169
12345