Asymmetric Synthesis of Allylic Sulfonic Acids: Enantio- and Regioselective Iridium-Catalyzed Allylations of Na2SO3

被引：18

作者：

Liu, Wei ^{[1
]}

Zhao, Xiao-ming ^{[1
]}

Zhang, Hong-bo ^{[1
]}

Zhang, Liang ^{[1
]}

Zhao, Ming-zhu ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

关键词：

enantioselectivity; regioselectivity; sodium sulfite; sulfonation; sulfonic acids; BETA-LACTAM ANTIBIOTICS; ALPHA; BETA-DISUBSTITUTED GAMMA-NITRO; ENANTIOSELECTIVE SYNTHESIS; CONJUGATE ADDITION; KINETIC RESOLUTION; SUBSTITUTION; ESTERS; ALKYLATION; CARBONATES; COMPLEXES;

D O I：

10.1002/chem.201405058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective allylation reaction of allylic carbonates with sodium sulfite (Na2SO3) catalyzed by Ir complex was accomplished, providing allylic sulfonic acids in good to excellent yields with a high level of enantio-and regioselectivities. (R)-2-Phenyl-2-sulfoacetic acid, a key intermediate for the synthesis of Cefsulodin and Sulbenicillin, was synthesized as well.

引用

页码：16873 / 16876

页数：4

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