Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease

被引：33
|
作者：
Guo, Yilin [1 ,2 ]
Zong, Shiyu [1 ,2 ,3 ]
Pu, Yiqiong [1 ]
Xu, Benliang [1 ]
Zhang, Tong [1 ,2 ]
Wang, Bing [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, 1200 Cailun Rd, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China
[3] Shaanxi Acad Tradit Chinese Med, Xian 710003, Shaanxi, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 07期
关键词：
targeted drug-delivery strategies; treatment; inflammatory bowel disease; IN-VIVO EVALUATION; DRUG-DELIVERY; ULCERATIVE-COLITIS; LOADED NANOPARTICLES; CHITOSAN MICROSPHERES; THERAPEUTIC-EFFICACY; INFLAMED TISSUE; BUDESONIDE; PH; LIPOSOMES;
D O I：
10.3390/molecules23071622
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is a common disease characterized by chronic inflammation in gastrointestinal tracts, which is primarily treated by administering anti-inflammatory and immunosuppressive drugs that inhibit the burden of intestinal inflammation and improve disease-related symptoms. However, the established therapeutic strategy has limited therapeutic efficacy and adverse drug reactions. Therefore, new disease-targeting drug-delivery strategies to develop more effective treatments are urgent. This review provides an overview of the drug-targeting strategies that can be used to treat IBD, and our recent attempts on the colon-specific delivery system (Pae-SME-CSC) with a paeonol-loaded self-microemulsion (Pae-SMEDDS) are introduced.
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收藏
页数：15
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