Modelling and indentification for the action of propofol and remifentanil on the BIS level

In this paper a model for the action of propofol and remifentanil on the BIS level suitably modified in order to provide the online identification of its parameters is proposed. Besides a novel identification method, which is compatible the usual clinical procedures, is also proposed. This method provides the identification of the 4 parameters of the model around the time of instant T-50, when BIS is equal to half of its maximum value. The new model design and identification method are validated by means of simulations, using a database of real cases in the framework of Galeno project, via a TCI (target-controled-infusion) scheme. Copyright (C) 2020 The Authors.