Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population

被引：50
|
作者：
Nguyen, L. T. [1 ,2 ]
Uchida, T. [1 ,3 ]
Tsukamoto, Y. [1 ]
Kuroda, A. [1 ,2 ]
Okimoto, T. [2 ]
Kodama, M. [2 ]
Murakami, K. [2 ]
Fujioka, T. [2 ]
Moriyama, M. [1 ]
机构：
[1] Oita Univ, Fac Med, Dept Mol Pathol, Yufu City, Oita 8795593, Japan
[2] Oita Univ, Fac Med, Dept Gastroenterol, Yufu City, Oita 8795593, Japan
[3] Oita Univ, Fac Med, Dept Human Environm & Social Med, Yufu City, Oita 8795593, Japan
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 08期
关键词：
Duodenal ulcer; dupA; gastric cancer; Helicobacter pylori; Japanese; ULCER-PROMOTING GENE; CAG PATHOGENICITY ISLAND; DUODENAL-ULCER; IV SECRETION; INFECTION; PATHOGENESIS; INFLAMMATION; GASTRITIS; RELEVANCE; STRAINS;
D O I：
10.1111/j.1469-0691.2009.03081.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
P>The dupA gene of Helicobacter pylori was suggested to be a risk factor for duodenal ulcer but protective against gastric cancer. The present study aimed to re-examine the role of dupA in H. pylori-infected Japanese patients. We found that dupA status was not associated with any gastroduodenal disease, histological score of chronic gastritis or with the extent of interleukin-8 production from gastric cell lines. These results indicate that dupA is unlikely to be a virulence factor of H. pylori in the Japanese population.
引用
收藏
页码：1264 / 1269
页数：6
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