Selective isomerization of a terminal olefin catalyzed by a ruthenium complex: The synthesis of indoles through ring-closing metathesis

被引：180
|
作者：
Arisawa, M [1 ]
Terada, Y [1 ]
Nakagawa, M [1 ]
Nishida, A [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期
关键词：
D O I：
10.1002/anie.200290031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aruthenium complex, generated from the Grubbs carbene catalyst with vinyloxytrimethylsilane, catalyzed the isomerization of terminal alkenes RCH2-CH=CH2 to internal alkenes RCH=CH-CH3. Application of this olefin isomerization to 2-(N-allylamino)styrene gave the corresponding enamines, which were converted into indoles by a standard ring-closing metathesis, see scheme (Ts = tosyl).
引用
收藏
页码：4732 / 4734
页数：3
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