Group-Based Trajectory Modeling to Identify Factors Influencing the Development of Myopia in Patients Receiving Orthokeratology

Purpose: To analyze the factors influencing the progression of myopia in adolescents receiving orthokeratology. Methods: This prospective cohort study collected the data of 378 myopia patients receiving orthokeratology. The follow-up time was 12 months ranging from December 2015 to December 2019. The group-based trajectory modeling (GBTM) was used to identify similar developmental trajectories in the levels of uncorrected visual acuity and changes of axial length elongation. Univariate and multivariate logistic regression analyses were conducted to explore the influencing factors of myopia development in patients wearing orthokeratology. Results: There was no factor having effect on visual acuity (left) and visual acuity (right) in different trajectories (all P>0.05). The corneal curvature K1 (left) (OR=0.382, 95% CI: 0.188-0.776), corneal curvature K2 (left) (OR=0.362, 95% CI: 0.187-0.699), degree of spherical refraction (left) (OR=0.139, 95% CI: 0.082-0.235) and spherical equivalent (left) (OR=7.276, 95% CI: 3.724-14.215) were factors associated with the changes of axial length elongation (left). The corneal curvature K1 (right) (OR=0.260, 95% CI: 0.116-0.585), corneal curvature K2 (left) (OR=0.272, 95% CI: 0.121-0.610) and degree of spherical refraction (right) (OR=0.129, 95% CI: 0.068-0.244) were correlated with the changes of axial length elongation (right). All P<0.05. Conclusion: Orthokeratology is a promising method for controlling the progression of myopia. The corneal curvature, degree of spherical refraction and spherical equivalent were factors influencing the changes of axial length elongation in myopia patients wearing orthokeratology. The findings might give a reference for the application of orthokeratology in clinic.