Synthesis and conformational analysis of macrocycles related to 10-oxa-epothilone

被引：5
|
作者：
Quintard, D
Bertrand, P
Bachmann, C
Gesson, JP
机构：
[1] Univ Poitiers, UMR 6514, F-86022 Poitiers, France
[2] CNRS, F-86022 Poitiers, France
[3] Univ Poitiers, UMR 6503, F-86022 Poitiers, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 23期
关键词：
aldolisation; epothilone; macrocycles; ring-closing metathesis;
D O I：
10.1002/ejoc.200400212
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short and convergent synthesis of macrocyclic factories related to 10-oxa-epothilone is based on aldolisation of a 3-(2'-methylallyloxy) aldehyde derived from methyl (2S)-3-hydroxy-2-methylpropionate followed by ring-closing metathesis. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
引用
收藏
页码：4762 / 4770
页数：9
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