Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori

被引：29
|
作者：
Marcial, G. [1 ,2 ]
Villena, J. [1 ]
Faller, G. [3 ]
Hensel, A. [2 ]
Font de Valdez, G. [1 ]
机构：
[1] Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos CERELA, Chacabuco 145, RA-4000 San Miguel De Tucuman, Tucuman, Argentina
[2] Univ Munster, Inst Pharmaceut Biol & Phytochem, Corrensstr 48, D-48149 Munster, Germany
[3] St Vincentius Hosp, Inst Pathol, Sudendstr 37, D-76137 Karlsruhe, Germany
来源：
BENEFICIAL MICROBES | 2017年 / 8卷 / 03期
关键词：
gastritis; stomach; inflammation; probiotic; pathogenic bacteria; S. thermophilus CRL1190; IN-VITRO; SIGNALING PATHWAYS; INHIBIT ADHESION; MICROORGANISMS; MILK; MODULATION; PREVENTION; GASTRITIS; STOMACH; STRAINS;
D O I：
10.3920/BM2016.0186
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H. pylori through the reduction of its adhesion and the modulation of the inflammatory response. Therefore, S. thermophilus CRL1190 fermented milk is a good candidate for further in vivo studying of the protective effect of functional food against H. pylori infection and gastric inflammatory damage.
引用
收藏
页码：451 / 461
页数：11
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