Chemical synthesis, spectroscopic analysis, antioxidant, and antimicrobial activities of some hydrazones derived from 4-fluorobenzohydrazide

Variously substituted 2,6-diphenylpiperidin-4-one 4-fluorobenzhydrazides were synthesized by direct condensation of the corresponding 2,6-diphenylpiperdin-4-one with 4-fluorobenzhydrazide. All the compounds are characterized by IR, NMR spectra readings. NMR spectral assignments are made unambiguously by their one-dimensional (H-1 NMR and C-13 NMR) NMR spectra. All the compounds have screened for their in vitro anti-oxidant and anti-bacterial activity in contradiction of various free radicals, and various bacterial strains respectively. The current study discloses that these compounds could be used as an outline for future development through derivatization to design more potent anti-oxidant and anti-microbial agents. Copyright (C) 2022 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the Third International Conference on Recent Advances in Materials and Manufacturing 2021