Antiphospholipid syndrome 2007.: Current aspects of laboratory diagnostics and their therapeutic consequences

被引:0
|
作者
Schuchmann, S.
Doerner, T.
机构
[1] Charite Univ Med Berlin, Interdisziplinare AG Klin Hamostaseol Immunol, D-10098 Berlin, Germany
[2] Charite Univ Med Berlin, Rheumatol Charite Ctr 14, D-10098 Berlin, Germany
[3] Deutsch Rheumaforsch Zentrum Berlin, Berlin, Germany
[4] Charite Univ Med Berlin, Neurowissensch Forschungszentrum, Berlin, Germany
来源
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2007年 / 66卷 / 03期
关键词
antiphospholipid antibodies; anticardiolipin antibodies; lupus anticoagulant; thrombosis; anticoagulation;
D O I
10.1007/s00393-007-0155-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent vascular thrombosis and loss of pregnancy in association with the presence of antiphospholipid antibodies (APA) detectable as lupus anticoagulants, anticardiolipin antibodies or anti-beta 2 glycoprotein I antibodies. The pathophysiological importance of APA in APS is accepted, however, the mechanisms leading to thrombosis are likely to be multifactorial and are so far unclear. Without a prior thrombosis, the risk of developing a new thrombosis in healthy patients with APA is slightly increased (< 1% per year). However, the risk of a recurrent thrombosis increases considerably (> 10% per year) in patients with a history of thrombosis without anticoagulation. The careful and correct identification of patients with APS is important because prophylactic anticoagulation can reduce the risk of recurrent thrombotic events, and during pregnancy can improve fetal and maternal outcome.
引用
收藏
页码:198 / 205
页数:8
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