Chronic myeloid leukemia: Proving ground for cancer stem cells

被引：24
|
作者：
Daley, GQ [1 ]
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp, Dept Biol Chem & Mol Pharmacol,Div Pediat Hematol, Boston, MA 02115 USA
来源：
CELL | 2004年 / 119卷 / 03期
关键词：
D O I：
10.1016/j.cell.2004.10.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A central question in cancer biology is whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in differentiated cells that acquire properties of unremitting self-renewal? In two papers, Weissman and colleagues document both mechanisms: chronic leukemia arising by mutation affecting the hematopoietic stem cell (HSC) and acute leukemia evolving from committed granulocyte-macrophage progenitors that have acquired the self-renewal machinery of HSCs.
引用
收藏
页码：314 / 316
页数：3
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