Tumor necrosis factor increases serum leptin levels in humans

被引：232
|
作者：
Zumbach, MS [1 ]
Boehme, MWJ [1 ]
Wahl, P [1 ]
Stremmel, W [1 ]
Ziegler, R [1 ]
Nawroth, PP [1 ]
机构：
[1] Heidelberg Univ, Med Klin, Dept Med, D-69115 Heidelberg, Germany
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1997年 / 82卷 / 12期
关键词：
D O I：
10.1210/jc.82.12.4080
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Leptin is a pleiotropic hormone believed to regulate body weight. Its function in wasting during inflammatory disease in humans is unknown. We studied the effect of repeated tumor necrosis factor (TNF) infusion on serum leptin levels in six patients with solid tumors. TNF infusion on day 1 resulted in an increase in serum leptin levels from 3.1 (SEM +/- 0.28) ng/mL to 5.2 (SEM +/- 0.6) ng/mL after 12 h (P < 0.001). The serum levels returned to baseline within 24 h. Similar results were obtained when TNF was infused on subsequent days. The study shows that leptin serum levels are under control of TNF.
引用
收藏
页码：4080 / 4082
页数：3
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