Cigarette smoking and progressive brain volume loss in schizophrenia

被引：21
|
作者：
Van Haren, N. E. M. [1 ]
Koolschijn, P. C. M. P. [1 ]
Cahn, W. [1 ]
Schnack, H. G. [1 ]
Pol, H. E. Hulshoff [1 ]
Kahn, R. S. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2010年 / 20卷 / 07期
关键词：
Schizophrenia; Longitudinal; MRI; Morphology; Smoking; GRAY-MATTER; MENTAL-ILLNESS; MR-IMAGES; PREVALENCE; INSTRUMENT; SCALE;
D O I：
10.1016/j.euroneuro.2010.02.009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码：454 / 458
页数：5
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