Binding Bacteria to Highly Branched Poly(N-isopropyl acrylamide) Modified with Vancomycin Induces the Coil-to-Globule Transition

被引:54
|
作者
Shepherd, Joanna [2 ,3 ]
Sarker, Prodip [1 ]
Swindells, Kathryn [1 ]
Douglas, Ian [3 ]
MacNeil, Sheila [2 ]
Swanson, Linda [1 ]
Rimmer, Stephen [1 ]
机构
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Univ Sheffield, Kroto Res Inst, Dept Mat Engn, Sheffield S3 7HQ, S Yorkshire, England
[3] Univ Sheffield, Sch Clin Dent, Sheffield S10 2TA, S Yorkshire, England
基金
英国工程与自然科学研究理事会;
关键词
STIMULI-RESPONSIVE POLYMERS; TEMPERATURE; INFECTIONS;
D O I
10.1021/ja907466y
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this Gram-positive bacteria (but not Gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.
引用
收藏
页码:1736 / +
页数:4
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