Facile one-pot synthesis of 4-substituted semicarbazides

被引：9

作者：

Bogolubsky, Andrey V. ^{[1
]}

Moroz, Yurii S. ^{[1
,2
]}

Mykhailiuk, Pavel K. ^{[1
,3
]}

Dmytriv, Yurii V. ^{[1
]}

Pipko, Sergey E. ^{[2
]}

Babichenko, Liudmyla N. ^{[1
,2
]}

Konovets, Anzhelika I. ^{[1
,4
]}

Tolmachev, Andrey ^{[1
,2
]}

机构：

[1] Enamine Ltd, UA-01103 Kiev, Ukraine

[2] Kyiv Natl Taras Shevchenko Univ, ChemBioCtr, UA-02094 Kiev, Ukraine

[3] Kyiv Natl Taras Shevchenko Univ, Dept Chem, UA-01601 Kiev, Ukraine

[4] Kyiv Natl Taras Shevchenko Univ, Inst High Technol, UA-03187 Kiev, Ukraine

来源：

RSC ADVANCES | 2015年 / 5卷 / 02期

关键词：

BIOLOGICAL EVALUATION; UNSYMMETRICAL UREAS; BLOCKED ISOCYANATES; DERIVATIVES; INHIBITORS; CARBONATE; DESIGN; THIOSEMICARBAZONES; ANTICONVULSANT; VERSATILITY;

D O I：

10.1039/c4ra12425a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diverse library of twenty-five 4-mono- and disubstituted semicarbazides was prepared in a one-pot two-step approach. The method includes formation of a carbamate from bis(2,2,2-trifluoroethyl)carbonate or 2,2,2-trifluoroethylchloroformate and a primary or secondary amine and subsequent interaction of the carbamate with hydrazine to result in a semicarbazide. The approach allowed to obtain 4-substituted semicarbazides on a large scale in good yield and high purity.

引用

页码：1063 / 1069

页数：7

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