Role of sympathetic nervous system in protective effects of selective κ-opiate receptor agonist dynorphin A1-13 on the incidence of cardiac arrhythmia during myocardial ischemia

被引:3
|
作者
Mikhailova, SD [1 ]
Vasil'eva, TV [1 ]
Semushkina, TM [1 ]
Storozhakov, GI [1 ]
机构
[1] Russian State Med Univ, Moscow 117437, Russia
关键词
dynorphin A(1-13); kappa-opiate receptors; myocardial ischemia; cardiac arrhythmia; stellate ganglion;
D O I
10.1007/BF02433859
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Preliminary administration of dynorphin A(1-13) to narcotized cats with myocardial ischemia attenuated cardiac fibrillation, but increased the incidence of ventricular tachycardia. Protective effect of dynorphin A(1-13) was observed only under conditions of intact sympathetic cardiac innervation.
引用
收藏
页码:27 / 29
页数:3
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