Evaluation of piperidinoethoxy moiety as an antiestrogenic substituent in non-steroidal anti-estrogens: Fertility regulation

被引：8
|
作者：
Tripathi, S
Dwivedy, I
Dhar, JD
Dwivedy, A
Ray, S
机构：
[1] CENT DRUG RES INST,DIV MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA
[2] CENT DRUG RES INST,DIV ENDOCRINOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(97)00379-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effect as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain. No significant difference in the antifertility activity in these two sets of compounds was observed. (C) 1997 Elsevier Science Ltd.
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页码：2131 / 2136
页数：6
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