Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy

被引:5
|
作者
Oldach, Maureen S. [1 ]
Ueda, Yu [2 ]
Ontiveros, Eric S. [1 ]
Fousse, Samantha L. [1 ]
Visser, Lance C. [1 ]
Stern, Joshua A. [1 ]
机构
[1] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, 1 Shields Ave, Davis, CA 95616 USA
[2] North Carolina State Univ, Dept Clin Sci, Coll Vet Med, Raleigh, NC 27606 USA
关键词
Feline; Pharmacodynamics; HCM; Obstruction; Inotrope;
D O I
10.1186/s12917-021-02799-9
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background Prior studies have suggested that pimobendan is associated with several positive effects in cats, including improved survival in cats with congestive heart failure and improved left atrial function in research colony cats with hypertrophic cardiomyopathy (HCM) and normal cats. However, there is still a paucity of pharmacodynamic data refuting or supporting the use of pimobendan in a clinical cat population. This clinical trial aimed to evaluate the pharmacodynamic effects and tolerability of a single dose of pimobendan in cats with HCM. Echocardiograms and Doppler-derived systolic blood pressures were performed in 21 client-owned cats with subclinical HCM at baseline and 90-min after oral administration of 1.25 mg of pimobendan (Vetmedin). Seven additional cats were evaluated post-placebo administration to account for intra-day variability. Results Heart rate, systolic blood pressure, and murmur grade were not significantly different between baseline and post-pimobendan evaluations. Left auricular blood flow velocity, left atrial size, and left ventricular fractional shortening were not significantly different between baseline and post-pimobendan evaluations. Mean (+/- standard deviation) tissue Doppler peak systolic velocity of the mitral annulus was significantly higher following pimobendan (7.4 cm/s +/- 1.5 vs 8.5 +/- 1.6; p = 0.02). Median (min, max) left-ventricular outflow tract maximum velocity was significantly higher following pimobendan [1.9 m/sec (1.5, 3.4) vs 2.6 m/sec (2.0, 4.0); p = 0.01]. Mean right-ventricular outflow tract maximum velocity was also significantly higher following pimobendan (1.5 m/s +/- 0.51 vs 2.0 +/- 0.53; p = 0.004). Mean left atrial fractional shortening was significantly higher following pimobendan (28% +/- 6 vs 32% +/- 7; p = 0.02). No adverse events were observed following pimobendan administration. Right ventricular outflow tract velocity was significantly higher following placebo in control cats (1.02 +/- 0.21 versus 1.31 +/- 0.31; p = 0.01). No other significant differences were detected. Conclusions In client-owned cats with HCM, pimobendan acutely increased left atrial function and mildly increased left ventricular systolic function. Left ventricular outflow tract velocity was increased after pimobendan. Pimobendan was well tolerated in the acute setting in cats with HCM. The findings of this prospective, acute-dosing study confirm previous findings in research animals and retrospective analyses and suggest that chronic dosing studies are safe and warranted.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy
    Maureen S. Oldach
    Yu Ueda
    Eric S. Ontiveros
    Samantha L. Fousse
    Lance C. Visser
    Joshua A. Stern
    [J]. BMC Veterinary Research, 17
  • [2] Effects of an iodine-restricted food on client-owned cats with hyperthyroidism
    van der Kooij, Marieke
    Becvarova, Iveta
    Meyer, Hein P.
    Teske, Erik
    Kooistra, Hans S.
    [J]. JOURNAL OF FELINE MEDICINE AND SURGERY, 2014, 16 (06) : 491 - 498
  • [3] Metabolizable energy intake of client-owned adult cats
    Thes, M.
    Koeber, N.
    Fritz, J.
    Wendel, F.
    Dobenecker, B.
    Kienzle, E.
    [J]. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2015, 99 (06) : 1025 - 1030
  • [5] Prevalence and Intensity of Otodectes cynotis in Client-owned Cats in Ahvaz, Iran
    Mosallanejad, B.
    Alborzi, A. R.
    Katvandi, N.
    [J]. ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2011, 6 (06): : 642 - 647
  • [6] EVALUATION OF THE ASSOCIATION BETWEEN LEPTOSPIRE SPECIES ANTIBODIES AND AZOTEMIA IN CLIENT-OWNED CATS
    Shropshire, S. B.
    Morris, A. K.
    Lappin, M. R.
    Veir, J. K.
    [J]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2013, 27 (03) : 731 - 731
  • [7] Seroprevalence of SARS-CoV-2 in Client-Owned Cats from Portugal
    Oliveira, Andreia
    Pereira, Maria Aires
    Mateus, Teresa Letra
    Mesquita, Joao R.
    Vala, Helena
    [J]. VETERINARY SCIENCES, 2022, 9 (07)
  • [8] EVALUATION FOR ASSOCIATIONS BETWEEN BARTONELLA SPECIES ANTIBODIES AND AZOTEMIA IN CLIENT-OWNED CATS
    Fabian, N. J.
    Crawford, P. C.
    Levy, J. K.
    [J]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2013, 27 (03) : 726 - 727
  • [9] Feline immunodeficiency virus testing in stray, feral, and client-owned cats of Ottawa
    Little, SE
    [J]. CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE, 2005, 46 (10): : 898 - 901
  • [10] Prevalence of hemoplasmas and Bartonella species in client-owned cats in Beijing and Shanghai, China
    Zhang, Yingxin
    Zhang, Zhixuan
    Lou, Yinying
    Yu, Yonglan
    [J]. JOURNAL OF VETERINARY MEDICAL SCIENCE, 2021, 83 (05): : 793 - 797