Immobilized vancomycin as chiral stationary phase in packed capillary liquid chromatography

被引：0
|
作者：
Svensson, LA [1 ]
Karlsson, KE
Karlsson, A
Vessman, J
机构：
[1] Astra Hassle AB, Dept Analyt Chem, S-43183 Molndal, Sweden
[2] Biomed Ctr, Dept Pharmaceut Chem, Uppsala, Sweden
来源：
CHIRALITY | 1998年 / 10卷 / 03期
关键词：
direct chiral separation; mobile phase composition; NSAIDs; retention model; vancomycin;
D O I：
10.1002/(SICI)1520-636X(1998)10:3<273::AID-CHIR10>3.0.CO;2-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fused silica-packed capillary columns containing vancomycin immobilized by reductive amination on an aldehyde-silica were used to separate enantiomers of some non-steroidal anti-inflammatory drugs. Attempts have been made to qualitatively explain the influence of various mobile phase compositions on the enantioselective retention. The effects of mobile phase pH, buffer, and organic modifier concentrations were investigated as well as the influence of salts of hydrophobic ions added to the mobile phase to induce ion pair retention. (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码：273 / 280
页数：8
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