Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver

被引:4
|
作者
Zhou, Heng [1 ]
Xu, Juling [2 ]
Huang, Sanxiong [3 ]
He, Ying [4 ]
He, Xiaowei [1 ]
Guo, Lu [1 ]
Yin, Shi [5 ]
Lu, Sheng [1 ]
机构
[1] Huzhou Univ, Affiliated Hosp 1, Peoples Hosp Huzhou 1, Dept Pharm, Huzhou 313000, Peoples R China
[2] Huzhou Univ, Med Sch, Huzhou 313000, Peoples R China
[3] First Peoples Hosp Huzhou, Dept Hepatobiliary Surg, Huzhou 313000, Peoples R China
[4] Huzhou Univ, Affiliated Hosp 1, Cent Lab, Zhejiang Prov Key Lab Media Biol & Pathogen Contr, Huzhou 313000, Peoples R China
[5] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Geriatr, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China
关键词
CHOLINERGIC ANTIINFLAMMATORY PATHWAY; ISCHEMIA/REPERFUSION INJURY; REGENERATION; CELLS; ACTIVATION; MECHANISMS; SURVIVAL; RECEPTOR; TARGETS;
D O I
10.1155/2021/6666428
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Liver ischemia-reperfusion injury (IRI) is an inevitable process during liver transplantation, hemorrhagic shock, resection, and other liver surgeries. It is an important cause of postoperative liver dysfunction and increased medical costs. The protective effects of the vagus nerve on hepatic IRI have been reported, but the underlying mechanism has not been fully understood. We established a hepatic vagotomy (Hv) mouse model to study the effect of the vagus on liver IRI and to explore the underlying mechanism. Liver IRI was more serious in mice with Hv, which showed higher serum ALT and AST activities and histopathological changes. Further experiments confirmed that Hv significantly downregulated the expression of IL-22 protein and mRNA in the liver, blocking the activation of the STAT3 pathway. The STAT3 pathway in the livers of Hv mice was significantly activated, and liver injury was clearly alleviated after treatment with exogenous IL-22 recombinant protein. In conclusion, Hv can aggravate hepatic IRI, and its mechanism may be related to inhibition of IL-22 expression and downregulation of the STAT3 pathway in the liver.
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页数:11
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