Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest

被引：16

作者：

Hou, Yanpeng ^{[1
]}

Cao, Shugeng ^{[1
]}

Brodie, Peggy J. ^{[1
]}

Miller, James S. ^{[2
,3
]}

Birkinshaw, Chris ^{[2
,3
]}

Andrianjafy, Mamisoa N. ^{[2
,3
]}

Andriantsiferana, Rabodo ^{[4
]}

Rasamison, Vincent E. ^{[4
]}

TenDyke, Karen ^{[5
]}

Shen, Yongchun ^{[5
]}

Suh, Edward M. ^{[5
]}

Kingston, David G. I. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA

[2] Missouri Bot Garden, St Louis, MO 63166 USA

[3] Missouri Bot Garden, Antananarivo 101, Madagascar

[4] Ctr Natl Applicat & Rech Pharmaceut, Antananarivo 101, Madagascar

[5] Eisai Inc, Andover, MA 01810 USA

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 5-6期

关键词：

Cassipourea lanceolata; Rhizophoraceae; Euphanes; Triterpenoids; NMR; Antiproliferative activity; GUIANENSIS; GERRARDII; ALKALOIDS;

D O I：

10.1016/j.phytochem.2009.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1-3. The (1)H and (13)C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC(50) values of 25, 25 and 32 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：669 / 674

页数：6

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