First example of the C-alkylation of indoles with Baylis-Hillman acetates

被引：47

作者：

Yadav, JS ^{[1
]}

Reddy, BVS ^{[1
]}

Basak, AK ^{[1
]}

Narsaiah, AV ^{[1
]}

Prabhakar, A ^{[1
]}

Jagadeesh, B ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 04期

关键词：

indium compounds; allylic substitution; heteroaromatics;

D O I：

10.1016/j.tetlet.2004.11.139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Baylis-Hillnian acetates undergo S(N)2' allylic substitution with indoles in the presence of 20 mol% of indium tribromide under mild conditions to afford a new class of substituted indoles in high yields with (E)-stereo selectivity. The stereochemistry of the products was assigned by various NMR experiments. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：639 / 641

页数：3

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