Ubiquitin biology: an old dog learns an old trick

被引：13
|
作者：
Pickart, CM [1 ]
机构：
[1] Johns Hopkins Univ, Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA
来源：
NATURE CELL BIOLOGY | 2000年 / 2卷 / 08期
关键词：
D O I：
10.1038/35019610
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulated protein degradation in eukaryotes occurs principally through covalent tagging of substrates with ubiquitin, thereby targeting them for destruction by 26S proteasomes. Classical allostery has now been added to the repertoire of mechanisms that can modulate ubiquitin tagging, allowing feed-forward regulation to be achieved through targeted protein destruction.
引用
收藏
页码：E139 / +
页数：3
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