Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides

被引：4
|
作者：
Suresha, G. P. [1 ]
Prakasha, K. C. [1 ]
Kapfo, Wethroe [1 ]
Gowda, D. Channe [1 ]
机构：
[1] Univ Mysore, Dept Chem, Mysore 570006, Karnataka, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 02期
关键词：
Antimicrobial drugs; Quinazolinone conjugated peptides; Hydrophobicity; Polarity; Chain length;
D O I：
10.1155/2010/979675
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Antimicrobial compounds were synthesized by coupling 4-(4-oxo-3,4- dihydroquinazolin-2-yl) butanoic acid with VP, GVP, VGVP and GVGVP peptides. Antimicrobial activities of the synthesized compounds were performed against various bacterial strains by disc diffusion method. The structure activity relationship was evaluated with respect to hydrophobicity, polarity, chain length of peptides and alkyl chain length of quinazolinone. Correlations of analogs with respect to their antimicrobial activity in comparison with conventional drugs and probable mechanism for the activity were discussed.
引用
收藏
页码：449 / 456
页数：8
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