Synthesis, Crystal Structure of A New Ternary Copper(II) Complex and Its Interaction with DNA

被引：0
|
作者：
Zhou Jian-Liang [1 ]
Chun Xiao-Gai [1 ]
Zhou Lin-Jiao [2 ]
Chen Yun [3 ]
Zhang Shou-Chun [1 ,2 ]
机构：
[1] Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[3] Hunan Univ, Sch Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
来源：
CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2010年 / 26卷 / 04期
关键词：
dppz; ternary copper(II) complex; DNA binding; DNA cleavage; CLEAVAGE ACTIVITY; HETEROCYCLIC BASES; ANTIMICROBIAL ACTIVITIES; STRAND SCISSION; METAL-COMPLEXES; NUCLEIC-ACIDS; BINDING; AGENTS; 1,10-PHENANTHROLINE; RECOGNITION;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new ternary copper(II) complex, [Cu(Dppz)(Gly)(H2O)]center dot NO3 center dot H2O (dppz =dipyrido [3,2-a:2',3'-c] phenazine, Gly=L-glycine), has been synthesized and structurally characterized. The complex crystallized in a monoclinic system with space group P2(1)/c, a=2.158 8(4) nm, b=0.721 6(13) nm, c=1.421 9(3) nm, beta=108.648(2)degrees. The five-coordinate copper(II) center is a distorted square pyramid. Absorption spectra and fluorescence spectra showed that there was interaction between the copper(II) complex and DNA through an intercalative mode. The complex exhibited efficient DNA cleavage activity in the presence of ascorbate. CCDC: 767873.
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页码：645 / 650
页数：6
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