Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography

被引：91
|
作者：
Carlucci, G
Palumbo, G
Mazzeo, P
Quaglia, MG
机构：
[1] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67010 Coppito, Laquila, Italy
[2] Univ Aquila, Dipartimento Med Interna & Sanita Pubbl, I-67010 Coppito, Laquila, Italy
[3] Univ Roma La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 01期
关键词：
HPLC; losartan potassium; hydrochlorothiazide; simultaneous determination; tablets;
D O I：
10.1016/S0731-7085(00)00268-5
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration lange 3.0-7.0 mu g ml(-1) for losartan and 0.5-2.0 mu g ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 mu g ml(-1) for losartan and 0.05 mu g ml(-1) for hydrochlorothiazide. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：185 / 189
页数：5
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