Pulmonary melanocytic nevus - A case report with a mutation analysis of common driver oncogenes

被引：3

作者：

Tanaka, Meiro ^{[1
]}

Matsumura, Mai ^{[1
]}

Okudela, Koji ^{[1
]}

Mitsui, Hideaki ^{[1
]}

Tateishi, Yoko ^{[1
]}

Umeda, Shigeaki ^{[1
]}

Suzuki, Takehisa ^{[1
]}

Koike, Chihiro ^{[1
]}

Kataoka, Toshiaki ^{[1
]}

Kawano, Naomi ^{[2
]}

Kojima, Yui ^{[2
]}

Osawa, Hiroyuki ^{[3
]}

Ohashi, Kenichi ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Pathol, Yokohama, Kanagawa, Japan

[2] Yokohama Minami Kyosai Hosp, Dept Pathol, Yokohama, Kanagawa, Japan

[3] Yokohama Minami Kyosai Hosp, Dept Surg, Yokohama, Kanagawa, Japan

来源：

PATHOLOGY INTERNATIONAL | 2019年 / 69卷 / 11期

关键词：

BRAF V600E; pulmonary melanoma; pulmonary nevus; UVEAL MELANOMA; NRAS MUTATIONS; BRAF MUTATIONS; GNAQ; IDENTIFICATION; GENES; KIT;

D O I：

10.1111/pin.12850

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Nevi are benign melanocytic tumors, and some nevi are considered to develop into malignant melanomas. Most nevi arise in the skin, but nevi occasionally occur in the conjunctiva, esophageal mucosa, or at other sites. Pulmonary melanocytic nevi are extremely rare, and only one case has been reported in the literature. Here, we present a case of pulmonary melanocytic nevus, involving a BRAF gene mutation (V600E), and we discuss the potential significance of this condition as a precursor to pulmonary malignant melanoma.

引用

页码：667 / 671

页数：5

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