Nasal-type NK/T cell lymphoma of the orbit with distant metastases

被引：27
|
作者：
Kuwabara, H
Tsuji, M
Yoshii, Y
Kakuno, Y
Akioka, T
Kotani, T
Iwao, N
Hanafusa, T
Ikeda, T
Mori, H
Mori, H
机构：
[1] Osaka Med Coll, Dept Pathol, Osaka 5698686, Japan
[2] Osaka Med Coll, Dept Internal Med, Osaka 5698686, Japan
[3] Osaka Med Coll, Dept Ophthalmol, Osaka 5698686, Japan
来源：
HUMAN PATHOLOGY | 2003年 / 34卷 / 03期
关键词：
lymphoma; orbit; NK/T cell; CD56;
D O I：
10.1053/hupa.2003.33
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is reported. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis. Lymphoma cells were positive for CD56, cytotoxic molecules (granzyme B and TIA-1), and EBV. Despite local radiotherapy, the patient had a highly aggressive clinical course. A postmortem examination revealed distant metastases to the heart and lungs exhibiting angiocentric growth. TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit. Copyright 2003, Elsevier Inc. All rights reserved.
引用
收藏
页码：290 / 292
页数：3
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