Carotid intima-media thickness in heavily pretreated HIV-infected patients

被引：56
|
作者：
Chironi, G
Escaut, T
Gariepy, J
Cogny, A
Monsuez, TJ
Levenson, J
Simon, A
Vittecoq, D
机构：
[1] Hop Broussais, Ctr Med Prevent Cardiovasc, F-75674 Paris 14, France
[2] Hop Broussais, CNRS, Unite UMR7131, F-75674 Paris 14, France
[3] Hop Paul Brousse, Serv Malad Infect & Trop, Villejuif, France
[4] Hop Europeen Georges Pompidou, Serv Biochim, Paris, France
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2003年 / 32卷 / 05期
关键词：
antiretroviral therapy; carotid arteries; HIV; intima-media thickness; risk factors;
D O I：
10.1097/00126334-200304150-00004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The authors used ultrasonography to measure carotid artery intima-media thickness (IMT) in 36 HIV-infected patients taking highly active antiretroviral therapy (cases) and in two control groups without (control group 1) or with (control group 2) blood lipid and glucose disturbances similar to those of the patients. Case IMT values were 8% higher than control group 1 IMT values (p < .05) but not different from control group 2 IMT values. Positive independent associations of IMT with the total-to-HDL cholesterol ratio and waist circumference existed for cases (p < .05) but not for controls. Case IMT did not correlate with parameters of HIV infection and antiretroviral treatment. This case-control study suggests that lipid disturbances, mainly hypo-HDLemia, may be involved in the early atherosclerotic process in HIV-infected patients.
引用
收藏
页码：490 / 493
页数：4
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