The association of pre-operative anaemia with survival after orthotopic liver transplantation

被引：14

作者：

Lichtenegger, P. ^{[1
]}

Schiefer, J. ^{[1
]}

Graf, A. ^{[2
]}

Berlakovich, G. ^{[3
]}

Faybik, P. ^{[1
]}

Baron, D. M. ^{[1
]}

Baron-Stefaniak, J. ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Anaesthesia Intens Care Med & Pain Med, Vienna, Austria

[2] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat, Vienna, Austria

[3] Med Univ Vienna, Dept Surg, Div Transplantat, Vienna, Austria

来源：

ANAESTHESIA | 2020年 / 75卷 / 04期

关键词：

end-stage liver disease; morbidity; mortality; orthotopic liver transplantation; outcome; pre-operative anaemia; transfusion; ACUTE KIDNEY INJURY; RED-BLOOD-CELLS; RISK-FACTORS; INTRAOPERATIVE TRANSFUSION; NONCARDIAC SURGERY; MORTALITY; OUTCOMES; MANAGEMENT; PATIENT; DEFINITION;

D O I：

10.1111/anae.14918

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Anaemia is common in patients with end-stage liver disease. Pre-operative anaemia is associated with greater mortality after major surgery. We analysed the association of pre-operative anaemia (World Health Organization classification) with survival and complications after orthotopic liver transplantation using Cox and logistic regression models. We included patients undergoing their first orthotopic liver transplantation between 2004 and 2016. Out of 599 included patients, 455 (76%) were anaemic before transplantation. Pre-operative anaemia was not associated with the survival of 485/599 (81%) patients to 1 year after liver transplantation, OR (95%CI) 1.04 (0.64-1.68), p = 0.88. Pre-operative anaemia was associated with higher rates of intra-operative blood transfusions and acute postoperative kidney injury on multivariable analysis, OR (95%CI) 1.70 (0.82-2.59) and 1.72 (1.11-2.67), respectively, p < 0.001 for both. Postoperative renal replacement therapy was associated with pre-operative anaemia on univariate analysis, OR (95%CI) 1.87 (1.11-3.15), p = 0.018.

引用

页码：472 / 478

页数：7

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