The Possible Useful Effectiveness of Sinapic Acid on Sepsis-Induced Secondary Organ Damage in Rats

被引：5

作者：

Tanyeli, Ayhan ^{[1
]}

Akdemir, Fazile Nur Ekinci ^{[2
]}

Eraslan, Ersen ^{[3
]}

Guler, Mustafa Can ^{[1
]}

Sebin, Saime Ozbek ^{[1
]}

Comakli, Selim ^{[4
]}

Gulcin, Ilhami ^{[5
]}

机构：

[1] Ataturk Univ, Fac Med, Dept Physiol, Erzurum, Turkey

[2] Ibrahim Cecen Univ Agri, Fac Hlth Sci, Dept Nutr & Dietet, Agri, Turkey

[3] Bozok Univ, Fac Med, Dept Physiol, Yozgat, Turkey

[4] Ataturk Univ, Fac Vet, Dept Patol, Erzurum, Turkey

[5] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey

来源：

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES | 2022年 / 12卷 / 01期

关键词：

Cecal ligation puncture; sinapic acid; lung; kidney; rat; CECAL LIGATION; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; INDUCED NEPHROTOXICITY; FREE-RADICALS; LUNG INJURY; IN-VITRO; INFLAMMATION; MODEL; APOPTOSIS;

D O I：

10.33808/clinexphealthsci.864015

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1 beta, caspase-3, and TNF-alpha immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.

引用

页码：134 / 140

页数：7

共 50 条

[1] Role of SGC isoforms in sepsis-induced organ dysfunction in rats
Doursour, Marie-Francoise J.
Liang, Yang Yan
Sharina, Iraida
Sharin, Vladislav
Murad, Ferid
CRITICAL CARE MEDICINE, 2007, 35 (12) : A52 - A52
[2] The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
Bacanli, Merve
Aydin, Sevtap
Taner, Gokce
Goktas, Hatice Gul
Sahin, Tolga
Basaran, A. Ahmet
Basaran, Nursen
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2014, 38 (03) : 774 - 782
[3] Mechanisms of sepsis-induced organ dysfunction
Abraham, Edward
Singer, Mervyn
CRITICAL CARE MEDICINE, 2007, 35 (10) : 2408 - 2416
[4] Oxytocin protects against sepsis-induced multiple organ damage:: Role of neutrophils
Iseri, SÖ
Sener, G
Saglam, B
Gedik, N
Ercan, F
Yegen, BÇ
JOURNAL OF SURGICAL RESEARCH, 2005, 126 (01) : 73 - 81
[5] NEUROPEPTIDE W ALLEVIATES HEPATORENAL OXIDATIVE DAMAGE IN SEPSIS-INDUCED RATS
Atici, Ali Emre
Tamer, Sevil Arabaci
Levent, Hilal Nisva
Eyuboglu, Irem Peker
Ercan, Feriha
Akkiprik, Mustafa
Yegen, Berrak C.
GASTROENTEROLOGY, 2020, 158 (06) : S1019 - S1019
[6] Protective effects of resveratrol on sepsis-induced DNA damage in the lymphocytes of rats
Aydin, S.
Bacanli, M.
Taner, G.
Sahin, T.
Basaran, A. A.
Basaran, N.
HUMAN & EXPERIMENTAL TOXICOLOGY, 2013, 32 (10) : 1048 - 1057
[7] Antigenotoxic effects of ferulic acid on sepsis-induced DNA damage in the liver and kidney of Wistar albino rats
Bacanli, M.
Aydin, S.
Taner, G.
Sahin, T.
Basaran, A. A.
Basaran, N.
TOXICOLOGY LETTERS, 2013, 221 : S125 - S125
[8] Mitochondrial mechanisms of sepsis-induced organ failure
Exline, Matthew C.
Crouser, Elliot D.
FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 : 5030 - 5041
[9] Role of sirtuins in sepsis and sepsis-induced organ dysfunction: A review
Yang, Xin-Ru
Wen, Ri
Yang, Ni
Zhang, Tie-Ning
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 278
[10] Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction
Sordi, R.
Fernandes, D.
Heckert, B. T.
Assreuy, J.
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (06) : 1289 - 1301

← 1 2 3 4 5 →