Cofactor NAD(P)H Regeneration Inspired by Heterogeneous Pathways

被引:343
|
作者
Wang, Xiaodong [1 ]
Saba, Tony [1 ]
Yiu, Humphrey H. P. [2 ]
Howe, Russell F. [3 ]
Anderson, James A. [1 ]
Shi, Jiafu [4 ]
机构
[1] Univ Aberdeen, Chem & Mat Engn, Sch Engn, Aberdeen AB24 3UE, Scotland
[2] Heriot Watt Univ, Chem Engn, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland
[3] Univ Aberdeen, Dept Chem, Aberdeen AB24 3UE, Scotland
[4] Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China
来源
CHEM | 2017年 / 2卷 / 05期
基金
中国国家自然科学基金;
关键词
DIRECT ELECTROCHEMICAL REGENERATION; NADH REGENERATION; ARTIFICIAL PHOTOSYNTHESIS; ENZYMATIC REDUCTION; NICOTINAMIDE COFACTORS; ORGANIC-SYNTHESIS; PHOTOCATALYTIC REGENERATION; INSITU REGENERATION; SOLAR-ENERGY; L-LACTATE;
D O I
10.1016/j.chempr.2017.04.009
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biocatalysis can empower chemical, pharmaceutical, and energy industries, where the use of enzymes facilitates low-energy, sustainable methods of producing high-value chemicals and pharmaceuticals that are otherwise impossibly troublesome or costly to obtain. One of the largest classes of enzymes (oxidoreductases, similar to 25% of the total) capable of promoting bioreduction reactions is vital for the global pharmaceutical and chemical market because of their intrinsic enantioselectivity and specificity. Enzymatic reduction depends on a coenzyme or cofactor as a hydride source, namely nicotinamide adenine dinucleotide (NADH) or its phosphorylated form (NADPH). Given the high cost, stoichiometric usage, and physical instability of NAD(P)H, a suitable method for NAD(P)H regeneration is essential for practical application. This review summarizes the existing methods for NAD(P)H regeneration, including enzymatic, chemical, homogeneous catalytic, electrochemical, photocatalytic, and heterogeneous catalytic routes. Particular focus is given to recent progress in developing heterogeneous systems with potential significance in terms of process simplicity, cleanliness, and energy and/or cost savings.
引用
收藏
页码:621 / 654
页数:34
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