Ultrastructural and immunohistochemical study of hepatic stellate cells over the course of infectious viral fibrosis and cirrhosis of the liver

被引：9
|
作者：
Nepomnyashchikh, G. I. [1 ]
Aidagulova, S. V. [1 ]
Nepomnyashchikh, D. L. [1 ]
Kapustina, V. I. [1 ]
Postnikova, O. A. [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Inst Reg Pathol & Pathomorphol, Dept Reg Pathol & Pathomorphol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 142卷 / 06期
关键词：
fibrosis and cirrhosis of the liver; liver biopsy; hepatic stellate cells; ultrastructure; immunohistochemistry;
D O I：
10.1007/s10517-006-0462-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The dynamics of structural and functional changes in stellate cells in liver biopsy specimens (from lipid-containing to fibrogenous phenotype) was studied during the development of infectious viral fibrosis and cirrhosis of the liver using ultrastructural, immunohistochemical, and morphometric methods. The priority role of stellate cells in the synthesis of extracellular matrix components is emphasized. Resorption of perihepatocellular collagen fibrils is associated with parenchymatous liver cells.
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页码：723 / 728
页数：6
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