Serum concentration of interferon-α:: A comparison between once-a-day and twice-a-day administration

被引：0

作者：

Matsukawa, Y

Nishinarita, S

Horie, T

Moriyama, M

Tanaka, N

Arakawa, Y

Kamei, S

Matsuura, M

Kojima, T

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 1, Tokyo 1738610, Japan

[2] Nihon Univ, Sch Med, Dept Internal Med 3, Tokyo 1738610, Japan

[3] Nihon Univ, Sch Med, Dept Neurol, Tokyo 1738610, Japan

[4] Nihon Univ, Sch Med, Dept Psychiat, Tokyo 1738610, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH | 2000年 / 20卷 / 1-2期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to determine the possible mechanism of the antiviral activity of twice daily administration of,if interferon (IFN)-alpha for active hepatitis C and to evaluate serum concentrations of IFN-cr with enzyme-linked immunosorbent assay (ELISA). Forty-seven patients with active hepatitis C received IFN-alpha intramuscularly far 24 weeks. They were divided into once-a-day and twice-a-day groups. Changes in serum IFN-alpha levels were assessed during the treatment period. Compared with twice-a-day treatment, the once-a-day group showed no increase in serum IFN-alpha. at the end of daily treatment (p <0.03). In contrast, one-third of the twice-a-day group showed increased IFN-<alpha> at the end of daily treatment (p <0.02). in conclusion, measured with ELISA, twice-daily administration of IFN-<alpha> manifested prolonged elevation,in serum levels when compared with once daily administration.

引用

页码：17 / 19

页数：3

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