Radiopharmaceuticals:: From molecular imaging to targeted radionuclide therapy

被引:9
|
作者
Schubiger, PA [1 ]
Grünberg, J [1 ]
Ametamey, SM [1 ]
Honer, M [1 ]
Garcia-Garayoa, E [1 ]
Bläuenstein, P [1 ]
Waibel, R [1 ]
Novak-Hofer, I [1 ]
Schibli, R [1 ]
机构
[1] ETH, PSI, Ctr Radiopharmacol Sci, CH-5232 Villigen, Switzerland
关键词
molecular imaging; PET-tracer; radioimmuno therapy; radionuclide therapy; radiopharmaceuticals;
D O I
10.2533/000942904777677489
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The research and development of smart radiodrugs is the goal of the Center of Radiopharmaceutical Science of ETH, PSI, and USZ. Positron Emission Tomography (PET) allows the non-invasive visualization of biochemical processes within the body. Radiolabeled PET-tracers allow the study of neurophysiological diseases like Alzheimer, Parkinson's disease or the imaging of metastatic tumors. PET-techniques are nowadays an important part of routine nuclear medicine diagnosis. Tumor-cell targeting biomolecules (e.g. antibodies or peptides) coupled to therapeutic radionuclides can sterilize the malignant cells while sparing healthy tissue. This so-called targeted radionuclide therapy has made tremendous progress in the recent years and the first approved radiotherapeutics are available for clinical use.
引用
收藏
页码:731 / 735
页数:5
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