Through the Looking Glass: Genome, Phenome, and Interactome of Salmonella enterica

被引:2
|
作者
Guard, Jean [1 ]
机构
[1] USDA ARS, US Natl Poultry Res Ctr, 950 Coll Stn Rd, Athens, GA 30605 USA
来源
PATHOGENS | 2022年 / 11卷 / 05期
关键词
Salmonella enterica; interactome; phenotype; genotype; serotype; speciation; whole genome sequencing; multi-locus sequence typing; salmonellosis; epidemiology; PHENOTYPE MICROARRAY ANALYSIS; LATERAL GENE-TRANSFER; SEROVAR ENTERITIDIS; UNITED-STATES; MULTISTATE OUTBREAK; EGG CONTAMINATION; LAYING HENS; TYPHIMURIUM; INFECTIONS; VIRULENCE;
D O I
10.3390/pathogens11050581
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
This review revisits previous concepts on biological phenomenon contributing to the success of the Salmonella enterica subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines.
引用
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页数:13
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