ADAMTS-4 in Central Nervous System Pathologies

被引：17

作者：

Lemarchant, Sighild ^{[1
]}

Wojciechowski, Sara ^{[1
]}

Vivien, Denis ^{[2
]}

Koistinaho, Jari ^{[1
]}

机构：

[1] Univ Eastern Finland, Bioctr Kuopio, AI Virtanen Inst Mol Sci, POB 1627, Kuopio 70211, Finland

[2] Univ Caen Basse Normandie, Serine Proteases & Pathophysiol Neurovasc Unit, INSERM, UMR S 919,GIP Cyceron, Bd H Becquerel,BP 5229, F-14074 Caen, France

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2017年 / 95卷 / 09期

基金：

芬兰科学院;

关键词：

ADAMTS-4; amyotrophic lateral sclerosis; acute CNS injuries; neuroplasticity; neuroinflammation; neurodegeneration; CHONDROITIN SULFATE PROTEOGLYCANS; TISSUE-PLASMINOGEN ACTIVATOR; SPINAL-CORD-INJURY; THROMBOSPONDIN MOTIFS; PERINEURONAL NETS; ABC PROMOTES; EXTRACELLULAR-MATRIX; FUNCTIONAL RECOVERY; TAU PATHOLOGY; MOUSE MODEL;

D O I：

10.1002/jnr.24021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is a metalloproteinase specialized in the degradation of chondroitin sulfate proteoglycans, contributing to cartilage breakdown during arthritis. In this review, we first focus on the modifications of ADAMTS-4 expression during CNS physiological and pathological conditions, including chronic diseases and injuries. Then, we discuss the contributions of ADAMTS-4 to mechanisms mediating neuroplasticity, neuroinflammation and neurodegeneration during spinal cord injury, ischemic stroke, amyotrophic lateral sclerosis and Alzheimer's disease. Here, we provide an overview of ADAMTS-4 functions and effects in the CNS, and we discuss directions for future studies and treatments. Overall, this review highlights that ADAMTS-4 is a unique multifaceted metalloproteinase which influences various CNS disease pathophysiologies. (C) 2017 Wiley Periodicals, Inc.

引用

页码：1703 / 1711

页数：9

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