Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene

被引：229
|
作者：
Glover, B [1 ]
Harvey, KA [1 ]
Liu, B [1 ]
Sharp, MJ [1 ]
Tymoschenko, MF [1 ]
机构：
[1] GlaxoSmithKline, Chem Dev, Res Triangle Pk, NC 27709 USA
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 03期
关键词：
D O I：
10.1021/ol027266q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The regioselective palladium(0)-catalyzed arylation of 3-furoate and 3-thiophenecarboxylate esters with aryl bromides is described. Conditions were developed that allow for the selective synthesis of either 2-aryl or 5-aryl products.
引用
收藏
页码：301 / 304
页数：4
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