Microenvironment of Liver Regeneration in Liver Cancer

被引:32
|
作者
Li Han-min [1 ,2 ,3 ]
Ye Zhi-hua [1 ,2 ,3 ]
机构
[1] Hubei Univ Chinese Med, Inst Applicat Fdn, Hubei Prov Hosp Tradit Chinese Med, Affiliated Hosp, Wuhan 430061, Hubei, Peoples R China
[2] Hubei Univ Chinese Med, Inst Liver Dis, Hubei Prov Hosp Tradit Chinese Med, Affiliated Hosp, Wuhan 430061, Hubei, Peoples R China
[3] Hubei Prov Acad Tradit Chinese Med, Wuhan 430074, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
liver regeneration microenvironment; liver cancer; tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; TGF-BETA; MET; HGF; PROGNOSIS; CELLS;
D O I
10.1007/s11655-017-2806-0
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of "tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment" can regulate "the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration"; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.
引用
收藏
页码:555 / 560
页数:6
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