Starch-Based Membranes for Controlled Release of 5-Fluorouracil In Vitro

被引：4

作者：

Berkkan, Aysel ^{[2
]}

Kondolot Solak, Ebru ^{[3
]}

Asman, Gulsen ^{[1
]}

机构：

[1] Gazi Univ, Fac Sci, Dept Chem, TR-06500 Emniyet Ankara, Turkey

[2] Gazi Univ, Fac Pharm, Dept Analyt Chem, TR-06330 Etiler Ankara, Turkey

[3] Gazi Univ, Dept Chem & Chem Engn Technol, Tech Sci Vocat Sch, TR-06374 Ostim Ankara, Turkey

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 23期

关键词：

5-fluorouracil; Drug delivery; Green chemistry; Polymer; Starch; PVA membrane; ACID-WATER MIXTURES; GLASS-TRANSITION; TARGETED DELIVERY; CROSS-LINKING; RICE STARCH; PERVAPORATION SEPARATION; MICROSPHERES; TEMPERATURE; DYNAMICS; CANCER;

D O I：

10.1002/slct.202100917

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starch is a natural polymer that is among the sustainable materials and has the characteristics of being a green material in harmony with nature. In this study, a potential transdermal release system was evaluated by investigating 5-fluorouracil (5-FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes in vitro. The effects of membrane thickness, starch/PVA blending ratio, pH, and temperature on the release of 5-FU from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount of 5-FU from starch/PVA membranes and 5-FU transfer from membranes could be controlled within a fairly constant range. The diffusion coefficient was determined as 4.84x 10(-3), 4.49x 10(-3) and 2.54x 10(-3) cm(2) s(-1) for the pH of 7.4, 5.5, and 3.5, respectively. The activation energy for the permeation 5-FU from starch/PVA membrane (60/40, v/v) was found to be 9.72 kJ mol(-1).

引用

页码：5678 / 5684

页数：7

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