NM23/nucleoside diphosphate kinase and signal transduction

被引：92
|
作者：
Otero, AD [1 ]
机构：
[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Sch Med, Charlottesville, VA 22908 USA
来源：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2000年 / 32卷 / 03期
关键词：
nucleoside diphosphate kinase; nm23; signal transduction; cytoskeleton; receptors; GTP binding proteins; phosphorylation;
D O I：
10.1023/A:1005589029959
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
NM23s (or NDP kinases) regulate a fascinating variety of cellular activities, including proliferation, development, and differentiation. All these processes are modulated by external stimuli, leading to the idea that this family of proteins modulates transmembrane signaling pathways. This review summarizes the evidence indicating that NM23/NDP kinases participate in transmembrane signaling in eukaryotic cells and discusses the molecular mechanisms proposed to account for these actions.
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页码：269 / 275
页数：7
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