Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder

被引：13
|
作者：
Gouvea, F. [1 ,2 ]
Lopes, A. [1 ,2 ]
Greenberg, B. [4 ]
Canteras, M. [3 ]
Taub, A. [1 ,2 ]
Mathis, M. [1 ,2 ]
Miguel, E. [1 ,2 ]
机构：
[1] Univ Sao Paulo, Sch Med, Dept Psychiat, BR-01060970 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Inst Psychiat, BR-01060970 Sao Paulo, Brazil
[3] Hosp Santa Paula, Inst Neurol Radiosurg, Sao Paulo, Brazil
[4] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA
来源：
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | 2010年 / 88卷 / 03期
关键词：
Capsulotomy; ventral; Obsessive-compulsive disorder; Radiosurgery; RELIABILITY; DEPRESSION; STRATEGIES; INVENTORY; VALIDITY; SCALE;
D O I：
10.1159/000313870
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This case regards a 34-year-old woman with severe and refractory obsessive-compulsive disorder, who was enrolled in a double-blind, randomized controlled trial of radiosurgery. She was at first submitted to a sham radiosurgical procedure, and 1 year later to an active intervention. Opposite clinical responses were observed in the follow-up of these different phases. During the sham surgery follow-up, no improvements were observed, but a remarkable amelioration was seen a few months after the active procedure. Detailed descriptions of psychopathological changes and neuroimaging findings as well as a discussion regarding the surgical technique are provided. Copyright (C) 2010 S. Karger AG, Basel
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页码：177 / 182
页数：6
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