ESTROGEN-INDUCTION OF STAT1 AND STAT4 EXPRESSION BY ESTROGEN RECEPTOR ALPHA SUGGESTS A NOVEL IFN-ALPHA-INDEPENDENT MECHANISM OF SEX-BIAS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATHOGENESIS

被引：0
|
作者：
Young, N. A. [1 ]
Wu, L. -C. [1 ]
Burd, C. [2 ]
Bruss, M. [1 ]
Valiente, G. [1 ]
Jarjour, W. [1 ]
机构：
[1] Ohio State Univ, Wexner Med Ctr, Rheumatol & Immunol, Columbus, OH 43210 USA
[2] Ohio State Univ, Wexner Med Ctr, Dept Mol Genet, Columbus, OH 43210 USA
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2014年 / 73卷
关键词：
D O I：
10.1136/annrheumdis-2014-eular.3909
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
AB0187
引用
收藏
页码：865 / 865
页数：1
相关论文
共 7 条
  • [1] Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
    Young, Nicholas A.
    Valiente, Giancarlo R.
    Wu, Lai-Chu
    Bruss, Michael
    Burd, Craig
    Jarjour, Wael N.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S274 - S274
  • [2] Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus
    Young, Nicholas
    Valiente, Giancarlo
    Wu, Lai-Chu
    Bruss, Michael
    Ardoin, Stacy
    Burd, Craig
    Jarjour, Wael N.
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S1175 - S1176
  • [3] Estrogen modulation of endosome-associated toll-like receptor 8: An IFNα-independent mechanism of sex-bias in systemic lupus erythematosus
    Young, Nicholas A.
    Wu, Lai-Chu
    Burd, Craig J.
    Friedman, Alexandra K.
    Kaffenberger, Benjamin H.
    Rajaram, Murugesan V. S.
    Schlesinger, Larry S.
    James, Hayley
    Shupnik, Margaret A.
    Jarjour, Wael N.
    CLINICAL IMMUNOLOGY, 2014, 151 (01) : 66 - 77
  • [4] Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
    Young, Nicholas A.
    Wu, Lai-Chu
    Burd, Craig
    Friedman, Alexandra
    Kaffenberger, Benjamin
    Rajaram, Murugesan
    Schlesinger, Larry S.
    James, Hayley
    Shupnik, Margaret
    Jarjour, Wael N.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S270 - S271
  • [5] Estrogen-regulated STAT1 activation promotes TLR8 expreSsion to facilitate signaling via microRNA-21 in systemic lupus erythematosus
    Young, Nicholas A.
    Valiente, Giancarlo R.
    Hampton, Jeffrey M.
    Wu, Lai-Chu
    Burd, Craig J.
    Willis, William L.
    Bruss, Michael
    Steigelman, Holly
    Gotsatsenko, Maya
    Amici, Stephanie A.
    Severin, Mary
    Claverie, Lucila Marino
    Guerau-de-Arellano, Mireia
    Lovett-Racke, Amy
    Ardoin, Stacy
    Jarjour, Wael N.
    CLINICAL IMMUNOLOGY, 2017, 176 : 12 - 22
  • [6] Estrogen-mediated TLR8 expression via STAT1 facilitates endogenous miRokine ligand activation through miR-21-containing exosomes: a novel innate inflammatory pathway in systemic lupus erythematosus
    Young, N. A.
    Wu, L.
    Amici, S.
    Guerau, M.
    Severin, M.
    Lovett-Racke, A.
    Valiente, G.
    Burd, C.
    Hampton, J.
    Jarjour, W. N.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2015, 33 (03) : S18 - S18
  • [7] ESTROGEN-REGULATED STAT1 ACTIVATION PROMOTES TLR8 OVEREXPRESSION AND FACILITATES MIROKINE SIGNALING VIA EXOSOMES CONTAINING MIR-21 ENDOGENOUS LIGAND: A NOVEL INNATE INFLAMMATORY PATHWAY IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Young, N. A.
    Wu, L. -C.
    Amici, S.
    Guerau, M.
    Severin, M.
    Lovett-Racke, A.
    Valiente, G.
    Burd, C.
    Hampton, J.
    Jarjour, W.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 906 - 907
1