Caffeine and cardiovascular diseases: critical review of current research

被引：66

作者：

Zulli, Anthony ^{[1
]}

Smith, Renee M. ^{[1
]}

Kubatka, Peter ^{[2
]}

Novak, Jan ^{[3
,4
,5
]}

Uehara, Yoshio ^{[6
]}

Loftus, Hayley ^{[1
]}

Qaradakhi, Tawar ^{[1
]}

Pohanka, Miroslav ^{[7
]}

Kobyliak, Nazarii ^{[8
]}

Zagatina, Angela ^{[9
]}

Klimas, Jan ^{[10
]}

Hayes, Alan ^{[1
]}

La Rocca, Giampiero ^{[11
,12
]}

Soucek, Miroslav ^{[3
,4
]}

Kruzliak, Peter ^{[13
]}

机构：

[1] Victoria Univ, Coll Hlth & Biomed, CCD, Melbourne, Vic 8001, Australia

[2] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Martin, Slovakia

[3] St Annes Univ Hosp, Dept Internal Med 2, Brno, Czech Republic

[4] Masaryk Univ, Brno, Czech Republic

[5] Masaryk Univ, Dept Physiol, Brno, Czech Republic

[6] Kyoritsu Womens Univ, Fac Home Econ, Div Clin Nutr, Tokyo, Japan

[7] Univ Def, Fac Mil Hlth Sci, Hradec Kralove, Czech Republic

[8] Bogomolets Natl Med Univ, Kiev, Ukraine

[9] Cardiol Ctr Med, St Petersburg, Russia

[10] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Odborarov 10, Bratislava 83232, Slovakia

[11] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Human Anat Sect, Palermo, Italy

[12] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy

[13] Univ Vet & Pharmaceut Sci, Fac Pharm, Lab Struct Biol & Prote, Palackeho Tr 1-1946, Brno 61242, Czech Republic

来源：

EUROPEAN JOURNAL OF NUTRITION | 2016年 / 55卷 / 04期

关键词：

Cardiovascular diseases; Caffeine; Cardioprotective effects; Pathogenesis; Clinical studies; Experimental studies; A(2A) RECEPTOR ANTAGONISM; COFFEE CONSUMPTION; RYANODINE RECEPTOR; ATRIAL-FIBRILLATION; DECAFFEINATED COFFEE; ADENOSINE RECEPTORS; INSULIN SENSITIVITY; METABOLIC SYNDROME; CEREBRAL-ISCHEMIA; HEALTHY-SUBJECTS;

D O I：

10.1007/s00394-016-1179-z

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains "Which dose is safe?", as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistical power. This review will focus on comprehensive and critical review of the current literature and provide an avenue for further study.

引用

页码：1331 / 1343

页数：13

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