Endothelial dysfunction and its correction wit cytoprotectors in patients with stable effort angina and arterial hypertension

被引：0
|
作者：
Khlebodarov, F. E. [1 ]
Turikov, P. Yu [1 ]
Mikhin, V. P. [1 ]
机构：
[1] Kursk State Med Univ, Chair Internal Dis 2, Kursk, Russia
来源：
RUSSIAN JOURNAL OF CARDIOLOGY | 2009年 / 06期
关键词：
Coronary heart disease; stable angina; arterial hypertension; cardiocytoprotectors; endothelial dysfunction; trimetazidine; mildronate;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The study compared the effects of cardiocytoprotectors (mildronate, trimetazidine) on endothelial function, physical stress tolerability, and circadian blood pressure (BP) profile in patients with arterial hypertension (AH; n=60) and stable angina (n=82), receiving anti-anginal therapy (beta-adrenoblockers, nitrates) or antihypertensive therapy (enalapril). Adding cardiocytoprotectors to the complex therapy improved endothelium-dependent vasodilatation and circadian BP profile, as well as reduced endothelial dysfunction severity and intima-media thickness in AH patients. Mildronate was more effective in improving endothelial structure and function.
引用
收藏
页码：34 / 39
页数：6
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