Do Probiotics in Pregnancy Reduce Allergies and Asthma in Infancy and Childhood? A Systematic Review

被引:24
|
作者
Colquitt, Alexander S. [1 ]
Miles, Elizabeth A. [1 ]
Calder, Philip C. [1 ,2 ,3 ]
机构
[1] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, Hants, England
[2] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England
[3] Univ Southampton, Southampton SO16 6YD, Hants, England
关键词
pregnancy; infancy; childhood; immune development; probiotic; microbiota; allergy; asthma; eczema; atopic dermatitis; EARLY-LIFE; HAY-FEVER; SUPPLEMENTATION; PREVENTION; PREVALENCE; DISEASE; TRIALS; RISK;
D O I
10.3390/nu14091852
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The maternal immune system is very important in the development of the foetal immune system. Probiotics have been shown to help regulate immune responses. Therefore, it is possible that the administration of probiotics to pregnant women could influence the development of the foetal immune system, reducing the likelihood of infants and children developing an allergic condition. The aim of this research was to conduct a systematic review to determine whether administering probiotics to pregnant women can reduce the incidence of allergic disease in their children. Medline, CINAHL and Embase databases were searched for randomised controlled trials (RCTs) that compared supplementation of probiotics to pregnant women to a placebo control and recorded the presentation of allergic conditions in their children. Data extracted from the study reports included their characteristics and findings. Study quality and risk of bias were assessed. From a total of 850 articles identified in the search, 6 were eligible for inclusion in this review. Two studies found no effect of maternal probiotics on the outcomes measured, two studies found that the incidence of eczema or atopic dermatitis (AD) was reduced by maternal probiotics, one study found no effect on the overall incidence of atopic sensitisation, but a reduction in a subgroup of children at high hereditary risk of allergic disease, and one study found no effect in an intention to treat analysis, but a reduction in AD in complete case analysis. The results of these studies are inconsistent but demonstrate that probiotics may have the potential to reduce infant allergies when administered prenatally, particularly in children at high risk of allergy development. There is a need for further larger-scale studies to be performed in order to provide a more definitive answer. Such studies should focus on at-risk groups.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Probiotics supplementation during pregnancy or infancy on multiple food allergies and gut microbiota: a systematic review and meta-analysis
    Jiang, Lan
    Zhang, Lili
    Xia, Jiayue
    Cheng, Lei
    Chen, Guoxun
    Wang, Jin
    Raghavan, Vijaya
    NUTRITION REVIEWS, 2024,
  • [2] Food diversity in infancy and the risk of childhood asthma and allergies
    Nwaru, Bright I.
    Takkinen, Hanna-Mari
    Kaila, Minna
    Erkkola, Maijaliisa
    Ahonen, Suvi
    Pekkanen, Juha
    Simell, Olli
    Veijola, Riitta
    Ilonen, Jorma
    Hyoty, Heikki
    Knip, Mikael
    Virtanen, Suvi M.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (04) : 1084 - 1091
  • [3] Do probiotics reduce adult lactose intolerance? A systematic review
    Levri, KM
    Ketvertis, K
    Deramo, M
    Merenstein, JH
    D'Amico, F
    JOURNAL OF FAMILY PRACTICE, 2005, 54 (07): : 613 - 620
  • [4] Childhood body mass index trajectories and asthma and allergies: A systematic review
    Chang, Chia-Lun
    Ali, Gulshan Bano
    Pham, Jonathan
    Dharmage, Shyamali C. C.
    Lodge, Caroline J. J.
    Tang, Mimi L. K.
    Lowe, Adrian J. J.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2023, 53 (09): : 911 - 929
  • [5] Pollen exposure in pregnancy and infancy and risk of childhood asthma
    Lundholm, Cecilia
    Almqvist, Catarina
    Ekberg, Sara
    Fang, Fang
    Fall, Tove
    Dahl, Aslog
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [6] Allergies/asthma and root resorption: a systematic review
    dos Santos, Cibelle Cristina Oliveira
    Bellini-Pereira, Silvio Augusto
    Medina, Melany Clarissa Gamez
    Normando, David
    PROGRESS IN ORTHODONTICS, 2021, 22 (01)
  • [7] Allergies/asthma and root resorption: a systematic review
    Cibelle Cristina Oliveira dos Santos
    Silvio Augusto Bellini-Pereira
    Melany Clarissa Gamez Medina
    David Normando
    Progress in Orthodontics, 22
  • [8] Sleep During Pregnancy and Offspring Outcomes From Infancy to Childhood: A Systematic Review
    Nevarez-Brewster, Melissa
    Han, Deborah
    Todd, Erin L.
    Keim, Paige
    Doom, Jenalee R.
    Davis, Elysia Poggi
    PSYCHOSOMATIC MEDICINE, 2025, 87 (01): : 7 - 32
  • [9] Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review
    Brown, Susan B.
    Reeves, Katherine W.
    Bertone-Johnson, Elizabeth R.
    NUTRITION REVIEWS, 2014, 72 (01) : 55 - 64
  • [10] Interventions to Reduce Harm from Smoking with Families in Infancy and Early Childhood: A Systematic Review
    Brown, Nicola
    Luckett, Tim
    Davidson, Patricia M.
    Di Giacomo, Michelle
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2015, 12 (03) : 3091 - 3119