Progesterone receptor-mediated up-regulation of transthyretin in preimplantation mouse uterus

被引：20
|
作者：
Diao, Honglu [1 ]
Xiao, Shuo [1 ,2 ]
Cui, Juan [3 ]
Chun, Jerold [4 ]
Xu, Ying [3 ]
Ye, Xiaoqin [1 ,2 ]
机构：
[1] Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA
[2] Univ Georgia, Interdisciplinary Toxicol Program, Athens, GA 30602 USA
[3] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
[4] Scripps Res Inst, Helen L Dorris Child & Adolescent Neuropsychiat D, Dept Mol Biol, La Jolla, CA 92037 USA
来源：
FERTILITY AND STERILITY | 2010年 / 93卷 / 08期
关键词：
EMBRYO IMPLANTATION; IODOTHYRONINE DEIODINASE; DELAYED-IMPLANTATION; GENE-EXPRESSION; THYROID-HORMONE; PROTEIN; FLUSHINGS; PREGNANCY; RETINOL; PLASMA;
D O I：
10.1016/j.fertnstert.2010.01.009
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Transthyretin (TTR), a carrier for thyroxine and retinol, has its messenger RNA (mRNA) expressed in the glandular endometrial epithelium and its protein detected in the glandular endometrial epithelium and the uterine lumen. TTR mRNA is dramatically up-regulated in the preimplantation mouse uterus as well as the P-treated ovariectomized mouse uterus, and in both situations the up-regulation of TTR is blocked by treatment with the P receptor antagonist RU486. (Fertil Steril (R) 2010; 93: 2750-3. (C) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码：2750 / 2753
页数：4
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